IGF-1 LR3

Long-acting analog of IGF-1, researched in muscle growth and repair.

Purity	>98%
Molecular formula	C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular weight	9117.60 Da
CAS number	946870-92-4

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1 mg 89.95€

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It arrives lyophilized: you need bacteriostatic water to reconstitute it.

Bacteriostatic water · 3 ml 4.95 € Bacteriostatic water · 10 ml 9.95 €

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For scientific research only. This product is not approved for human, veterinary or diagnostic use. By purchasing it you confirm that you will use it exclusively for laboratory research purposes.

Research background

IGF-1 LR3 is an analog of insulin-like growth factor 1 with two changes: a substitution at position 3 and a thirteen amino acid extension at the N-terminus. Both reduce its affinity for the binding proteins (IGFBPs), which in the body sequester most of the circulating IGF-1.

That is the reason it is used: circulating free, it lasts longer and is considerably more potent than native IGF-1 in culture. It is in fact a routine reagent in cell culture media and industrial bioprocessing, where it is used to sustain the proliferation of cell lines. In research it is studied around the IGF-1R/PI3K/Akt pathway, in cell growth and in muscle tissue repair.

Reconstitution and handling

Work on a clean surface and disinfect the vial stopper with an alcohol wipe before piercing it.
Add the bacteriostatic water slowly, letting it run down the inner wall of the vial rather than landing on the powder.
Do not shake. Swirl the vial gently until the lyophilized powder has fully dissolved: vigorous agitation degrades the peptide.
The solution should come out clear. If it turns cloudy or shows suspended particles, do not use it.

Storage and stability

Before reconstitution: refrigerated between 2 and 8 °C, protected from light and moisture.
After reconstitution: in the fridge and away from light. In solution the peptide lasts far less than as a powder, so it is best used soon.
Avoid freeze-thaw cycles.