KPV

C-terminal tripeptide of α-MSH, researched in inflammatory signalling, epithelial barrier and mucosal immunity.

Purity	≥99%
Molecular formula	C₁₆H₃₀N₄O₄
Molecular weight	342.43 Da
CAS number	67727-97-3

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10 mg 59.95€

30 mg 129.95€

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It arrives lyophilized: you need bacteriostatic water to reconstitute it.

Bacteriostatic water · 3 ml 4.95 € Bacteriostatic water · 10 ml 9.95 €

Total

Limited stock, restocked by lot — ships in 24-72h while units are available.

Order before 12:00 and it ships today (Mon–Sat)
Free shipping on orders from 150 €
Below that: 7,99 € to Spain · 12,99 € to the rest of the EU

For scientific research only. This product is not approved for human, veterinary or diagnostic use. By purchasing it you confirm that you will use it exclusively for laboratory research purposes.

Research background

KPV (Lys-Pro-Val) is the last three amino acids of α-MSH, the melanocyte stimulating hormone. The whole molecule activates melanocortin receptors; this fragment retains part of the anti-inflammatory activity described for α-MSH without the pigmentary component, and that is where its interest lies: it lets the two branches of one hormone be separated in the lab.

What is published concentrates on cell models of intestinal and cutaneous inflammation, where its entry into the cell through the PepT1 peptide transporter and its effect on the NF-κB pathway and the production of pro-inflammatory cytokines are studied. Being such a small tripeptide, it also appears as a reference in stability and topical formulation work.

Reconstitution and handling

Work on a clean surface and disinfect the vial stopper with an alcohol wipe before piercing it.
Add the bacteriostatic water slowly, letting it run down the inner wall of the vial rather than landing on the powder.
Do not shake. Swirl the vial gently until the lyophilized powder has fully dissolved: vigorous agitation degrades the peptide.
The solution should come out clear. If it turns cloudy or shows suspended particles, do not use it.

Storage and stability

Before reconstitution: refrigerated between 2 and 8 °C, protected from light and moisture.
After reconstitution: in the fridge and away from light. In solution the peptide lasts far less than as a powder, so it is best used soon.
Avoid freeze-thaw cycles.