Cellular metabolism & antioxidants
5-Amino-1MQ
Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), researched in adipocytes and in animal models of energy metabolism.
| Purity | >98% |
| Molecular formula | C10H11IN2 |
| Molecular weight | 286.11 Da |
| CAS number | 42464-96-0 |
Research background
Unlike the rest of the catalogue, 5-Amino-1MQ is not a peptide but a small molecule: the iodide salt of the 5-amino-1-methylquinolinium cation. The interest in it comes from the enzyme it inhibits, nicotinamide N-methyltransferase (NNMT), which methylates nicotinamide using methyl groups from S-adenosylmethionine and producing 1-methylnicotinamide; that reaction connects to the NAD+ salvage pathway and to the cell's balance of methyl donors.
The literature is preclinical. The reference work describes small, selective, membrane-permeable NNMT inhibitors: in 3T3-L1 adipocytes they reduce lipogenesis and lower 1-methylnicotinamide levels, and in diet-induced obese mice their effect on adiposity was studied (Neelakantan et al., Biochem Pharmacol 2018). This is work in cells and in mice: there are no published clinical trials supporting it in humans.
Reconstitution and handling
- Work on a clean surface and disinfect the vial stopper with an alcohol wipe before piercing it.
- Add the bacteriostatic water slowly, letting it run down the inner wall of the vial rather than landing on the powder.
- Do not shake. Swirl the vial gently until the lyophilized powder has fully dissolved: vigorous agitation degrades the peptide.
- The solution should come out clear. If it turns cloudy or shows suspended particles, do not use it.
