DSIP

Nonapeptide isolated in 1974 from rabbit brain, researched in slow-wave sleep, the hypothalamic-pituitary-adrenal axis and the stress response.

Purity	≥99%
Molecular formula	C₃₅H₄₈N₁₀O₁₅
Molecular weight	848.80 Da
CAS number	62568-57-4

Select size:

10 mg 79.95€

Complete your order

It arrives lyophilized: you need bacteriostatic water to reconstitute it.

Bacteriostatic water · 3 ml 4.95 € Bacteriostatic water · 10 ml 9.95 €

Total

Limited stock, restocked by lot — ships in 24-72h while units are available.

Order before 12:00 and it ships today (Mon–Sat)
Free shipping on orders from 150 €
Below that: 7,99 € to Spain · 12,99 € to the rest of the EU

For scientific research only. This product is not approved for human, veterinary or diagnostic use. By purchasing it you confirm that you will use it exclusively for laboratory research purposes.

Research background

DSIP was born of one specific experiment: Monnier and Schoenenberger induced sleep by electrical stimulation in rabbits, collected cerebral venous blood and isolated from it a nonapeptide which, transferred to other animals, was associated with an increase in delta waves. Hence the name, which describes the assay it appeared in and not a mechanism.

Half a century later that mechanism is still not settled, and that is what makes DSIP interesting as a tool: no receptor of its own has been identified for it. The literature studies it by indirect routes — modulation of ACTH and LH release, thermoregulation, interaction with opioidergic systems — and still debates whether it circulates as an endogenous peptide with a function of its own or as a fragment of something larger.

It is also one of the few peptides of its size described as crossing the blood-brain barrier in both directions, and that property has made it a recurring reference in work on the transport and stability of small peptides.

Reconstitution and handling

Work on a clean surface and disinfect the vial stopper with an alcohol wipe before piercing it.
Add the bacteriostatic water slowly, letting it run down the inner wall of the vial rather than landing on the powder.
Do not shake. Swirl the vial gently until the lyophilized powder has fully dissolved: vigorous agitation degrades the peptide.
The solution should come out clear. If it turns cloudy or shows suspended particles, do not use it.

Storage and stability

Before reconstitution: refrigerated between 2 and 8 °C, protected from light and moisture.
After reconstitution: in the fridge and away from light. In solution the peptide lasts far less than as a powder, so it is best used soon.
Avoid freeze-thaw cycles.